The other answers are telling you how you can remove a set of numbers from another set. Reading your question I think you want what's in the first but not in the second, and viceversa:
var numbers1 = new [] { 2.0, 2.1, 2.2, 2.3, 2.4, 2.5 };
var numbers2 = new [] { 2.2, 2.8 };
var intersect = numbers1.Intersect(numbers2);
var diff = numbers1.Concat(numbers2).Except(intersect);