This is not possible with the magic find methods. Try using the query builder:
$result = $em->getRepository("Orders")->createQueryBuilder('o')
->where('o.OrderEmail = :email')
->andWhere('o.Product LIKE :product')
->setParameter('email', 'some@mail.com')
->setParameter('product', 'My Products%')
->getQuery()
->getResult();