I may be doing something wrong, but I have been trying to install pyside on Mac 10.12 (Sierra). Here is what I tried (after installing Qt with brew):
The Mac steps from here worked for me: https://fredrikaverpil.github.io/2016/08/17/compiling-pyside2/
You’ll need the Xcode commandline tools:
xcode-select --install
sudo xcodebuild -license
Then the following packages, easily installed via brew:
brew install qt5 cmake libxslt libxml2
Clone the pyside-setup repository and have it also pull down its gitmodules:
git clone --recursive https://codereview.qt-project.org/pyside/pyside-setup
Build it. This command worked fine for me using Python 2.7.11 and Python 3.5.1. Remember to have pip installed with the wheel package or you’ll get an error about bdist_wheel.
cd pyside-setup
python setup.py bdist_wheel --ignore-git --qmake=/usr/local/Cellar/qt5/5.6.1-1/bin/qmake --cmake=/usr/local/bin/cmake --openssl=/usr/local/Cellar/openssl/1.0.2h_1/bin
Last but not least, install the wheel:
cd dist
pip install PySide2-2.0.0.dev0-cp27-cp27m-macosx_10_12_x86_64.whl
All credits go to Fredrik Averpil's wonderful post.