I\'m testing our JavaScript-heavy web application on Windows 8. For what it seems, IE10 on desktop works just fine. However, the Metro UI version for IE10 seems to break our app
The rendering/ JS Engine in IE10 Desktop and IE10 should be identical. Does your app use any Add-ins (for things like cut and paste support?) As far as I am aware taking IE10 Desktop and switching off plugin support should be the same as running your app in "non desktop IE10"
As for debugging, you can't get tools to run in IE10 desktop mode. I often use fiddler to inspect the traffic, but you will need to enable loopback on the machine to get this running for Metro IE.
You could add firebug lite to get basic dev tools.