For a computer working with a 64 bit processor, the largest number that it can handle would be 264 = 18,446,744,073,709,551,616. How does programming languages, say J
You assume the wrong thing. The biggest number it can handle in a single register is a 64-bits number. However, with some smart programming techniques, you could just combined a few dozens of those 64-bits numbers in a row to generate a huge 6400 bit number and use that to do more calculations. It's just not as fast as having the number fit in one register.
Even the old 8 and 16 bits processors used this trick, where they would just let the number overflow to other registers. It makes the math more complex but it doesn't put an end to the possibilities.
However, such high-precision math is extremely unusual. Even if you want to calculate the whole national debt of the USA and store the outcome in Zimbabwean Dollars, a 64-bits integer would still be big enough, I think. It's definitely big enough to contain the amount of my savings account, though.