Not in terms of readability, naturally, since you can always arrange the separate methods into separate lines. Rather, is it dangerous, for any reason, to chain an excessively l
The only consern you should consider regarding this (if yor ignoring readability) is resource handling and GC.. Questions you should ask are.
But really.. weather you call one method per line, or string them all togeather its all ends up being the same in IL (or very nearly the same).
Josh