The new Tweetdeck for the Mac is supposedly HTML5-based:
http://www.cultofmac.com/134237/tweetdeck-releases-html5-based-app-in-the-mac-app-store/
Anyone know how
http://nwjs.io/
NW.js lets you call all Node.js modules directly from DOM and enables a new way of writing applications with all Web technologies. It was previously known as "node-webkit" project.