The new Tweetdeck for the Mac is supposedly HTML5-based:
http://www.cultofmac.com/134237/tweetdeck-releases-html5-based-app-in-the-mac-app-store/
Anyone know how
Today you have some great tools made to build Mac OS X applications with HTML5/CSS3 and JavaScript. Like Sentenza Desktop : http://codecanyon.net/item/sentenza-desktop-for-mac/4070984