In Kafka 0.8beta a topic can be created using a command like below as mentioned here
bin/kafka-create-topic.sh --zookeeper localhost:2181 --replica 2 --parti
Note: My answer covers Kafka 0.8.1+, i.e. the latest stable version available as of April 2014.
Yes, you can create a topic programatically via the Kafka API. And yes, you can specify the desired number of partitions as well as the replication factor for the topic.
Note that the recently released Kafka 0.8.1+ provides a slightly different API than Kafka 0.8.0 (which was used by Biks in his linked reply). I added a code example to create a topic in Kafka 0.8.1+ to my reply to the question How Can we create a topic in Kafka from the IDE using API that Biks was referring to above.