A colleague and I have spent a few years developing a really cool Matlab application, MDLcompress. Within Matlab, I can type \"MDLcompress(\'filename.txt\')\" and it will tell
If you are mostly proficient in MATLAB you can write web application in MATLAB with MATLAB Web Server
Edit:
Matlab Web Server is discontinued, so it is not for you if you use recent version of Matlab. May be this tutorial will help to create CGI module from Matlab code.