Serving Python (Flask) REST API over HTTP2

Question

I have a Python REST service and I want to serve it using HTTP2. My current server setup is nginx -> Gunicorn. In other words, nginx (port 443 and 80 that redire

Answer 1

It is now possible to serve HTTP/2 directly from a Python app, for example using Twisted. You asked specifically about a Flask app though, in which case I'd (with bias) recommend Quart which is the Flask API reimplemented on top of asyncio (with HTTP/2 support).

Your actual issue,

With HTTP1.0 and Python Requests as the client, each request takes ~80ms

suggests to me that the problem you may be experiencing is that each request opens a new connection. This could be alleviated via the use of a connection pool without requiring HTTP/2.