I am using using VS2010 and if I have a form open in designer mode and run my application the designer tab will no longer show the form designer but instead an error will be di
"In the project file (.vcxproj), locate the entry for the target
Framework version. For example, if your project is designed to use the
.NET Framework 4.5, locate
v4.5 in the
element of the element. "
(Microsoft)
In my case the "v4.5" didn't exist so I add it, and everything is good now.