How to replace the some characters from the end of a string?

Question

I want to replace characters at the end of a python string. I have this string:

 s = \"123123\"

I want to replace the last 2 with

Answer 1

Here is a solution based on a simplistic interpretation of your question. A better answer will require more information.

>>> s = "aaa bbb aaa bbb"
>>> separator = " "
>>> parts = s.split(separator)
>>> separator.join(parts[:-1] + ["xxx"])
'aaa bbb aaa xxx'

Update

(After seeing edited question) another very specific answer.

>>> s = "123123"
>>> separator = "2"
>>> parts = s.split(separator)
>>> separator.join(parts[:-1]) + "x" + parts[-1]
'1231x3'

Update 2

There is far better way to do this. Courtesy @mizipzor.